ABSTRACT
OBJECTIVE:To explore the dynamic upwarp state correction coefficient of cyclosporine blood concentration determined by EMIT. METHODS:The dynamic upwarp state of cyclosporine concentration was determined by EMIT. The cyclosporine calibration reagents with concentration of 100 ng/mL was used as the sample to be measured,the 58th and 101st test results were selected to simulate the dynamic upwarp state related coefficients,and the 1st,20th,45th,77th,106th,115th test results were corrected by above coefficients. The difference of correction quality concentration with real quality concentration was investigated. RESULTS:The dynamic upwarp state coefficient [k=(1+0.001 235×n0.419 5)n] and dynamic upwarp state correction coefficient {k′=1/[(1+0.001 235×n0.419 5)n} were obtained. After determination results were corrected,relative error of corrected quality concentration with real quality concentration was within ± 4%.CONCLUSIONS:The obtained dynamic upwarp state correction coefficient can be used for dynamic calibration of cyclosporine quality control concentration,which contribute to correct determination of blood concentration of cyclosporine.
ABSTRACT
OBJECTIVE:To evaluate the application of mixture design in the design of formulation.METHODS:Isosorbide mononitrate (ISMN) was used as model drug,and the formulation of ISMN sustained-release tablet was optimized by the mixture design.The optimized ISMN sustained-release tablets were compared with the ISMN sustained-release tablets in market in respect of the release rate in vitro.RESULTS:The comparison between the validating value and the target value of the optimized sample showed a similarity factor(f2) of 86.56,and there were no differences between the optimized sample and that in market in respect of the drug release in vitro.CONCLUSION:The mixture design is applicable for the optimization of formulation and it can be used to predict the drug release in vitro.
ABSTRACT
OBJECTIVE:To direct rational use of drugs in the clinic by applying pharmacokinetic theory.METHODS:A new formula practicable for clinic was derived by expanding and transforming the basic pharmacokinetic formula.A practical pharmacokinetic parameter table was established and from which the pharmacokinetic parameters needed by clinic were avail?able.RESULTS:With the help of practical pharmacokinetic parameter table,the rationality of clinical medication can be in?vestigated at any time.Combined with monitoring of blood concentration,personalized medicine can be realized.CONCLU?SION:The practical pharmacokinetic parameter table is an important tool in directing personalized medicine.
ABSTRACT
OBJECTIVE:To explore the best way of drug application&taking in pharmacy through computer.METH-ODS:Ratio ordering method was applied to the high and low limit setups of drug stocks.RESULTS:The timely and dynamic high and low limit data setups through computer has successfully overcome the drawbacks of those from manual labor,thus more scientific and rapid drug application&taking was available.CONCLUSION:Ratio ordering method deserves to be generalization and application in drug application&taking by computer.